Penn Station East Coast Subs is located at 654 Main St, Cincinnati, OH. This location is in the Central Business District neighborhood. This business specializes in Sandwiches. Penn Station East Coast Subs is open Mon. - Wed. 10am - 7pm;Thu. - Fri. 10am - 8pm;Sat. 11am - 6pm;Sun. CLOSED and accepts Cash, Mastercard and Visa.