Cafe Jefferson is located at 293 Jefferson Ave, Salem, MA. This location is in the Salem Neck neighborhood. This business specializes in Cafes and has 2 review(s) with a star rating of 5.0. Cafe Jefferson is open Mon, 7am-3pm; Tue, 7am-3pm; Wed, 7am-3pm; Thu, 7am-3pm; Fri, 7am-3pm; Sat, 7am-2pm; Sun, 7am-2pm and accepts Cash, Mastercard and Visa.