Grape and Grain is located at 227 S San Mateo Dr, San Mateo, CA. This business specializes in Food & Dining. Grape and Grain is open Mon, Closed ; Tue, 4pm-9pm ; Wed, 4pm-9pm ; Thu, 4pm-9pm ; Fri, 3pm-10pm ; Sat, 3pm-10pm ; Sun, 2pm-6pm. and accepts Cash, Mastercard and Visa.