Main Street Cafe is located at 182 Main St, Marlborough, MA. This business specializes in Cafes. Main Street Cafe is open Mon, 7am-5pm; Tue, 7am-5pm; Wed, 7am-5pm; Thu, 7am-8pm; Fri, 7am-8pm; Sat, 6:05am-3pm; Sun, 7am-12pm and accepts American Express, Cash, Discover, Mastercard and Visa.