Main Street Grill is located at 5749 Main St, New Port Richey, FL. This location is in the Town of New Port Richey neighborhood. This business specializes in Restaurants. Main Street Grill is open Mon, 10am-9pm; Tue, 10am-9pm; Wed, 10am-9pm; Thu, 10am-9pm; Fri, 11am-12pm; Sat, 11am-10pm; Sun, Closed and accepts American Express, Discover, Mastercard and Visa.