Office Depot is located at 5900 Rivers Ave, North Charleston, SC. This business specializes in Office Supplies & Services. Office Depot is open Mon, 8am-9pm; Tue, 8am-9pm; Wed, 8am-9pm; Thu, 8am-9pm; Fri, 8am-9pm; Sat, 9am-9pm; Sun, 10am-6pm and accepts Apple Pay.