US Post Office is located at 5580 Main St, Dryden, MI. This business specializes in Post Offices. US Post Office is open Mon, 8:05am-4:05pm; Tue, 8:05am-4:05pm; Wed, 8:05am-4:05pm; Thu, 8:05am-4:05pm; Fri, 8:05am-4:05pm; Sat, 9am-12am; Sun, Closed and accepts American Express, Discover, Mastercard and Visa.