Zaxby's is located at 1041 Sams Crossing Rd, Columbia, SC. This business specializes in Family Style Restaurants and Restaurants. Zaxby's is open Mon, 10:05am-11pm; Tue, 10:05am-11pm; Wed, 10:05am-11pm; Thu, 10:05am-11pm; Fri, 10:05am-11pm; Sat, 10:05am-11pm; Sun, 11am-10pm and accepts American Express, Cash, Discover, Mastercard and Visa.